Diets deficient in selenium and vitamin E affect plasma lipoprotein and apolipoprotein concentrations in the rat.

نویسندگان

  • A Mazur
  • F Nassir
  • E Gueux
  • C Moundras
  • J Bellanger
  • P Grolier
  • E Rock
  • Y Rayssiguier
چکیده

The present study examined the effects of Se, vitamin E and combined Se and vitamin E deficiencies in rats on plasma lipid, lipoprotein and apolipoprotein (apo) concentrations. Deficiencies were induced by feeding rats the respective diets for 6 weeks. The study shows that Se deficiency results in increased concentrations of plasma cholesterol and apo E. Both could be explained by an increase in the HDL1 fraction. Vitamin E deficiency alone had no significant effect on plasma lipid, lipoprotein and apo concentrations. Se deficiency in combination with vitamin E deficiency leads to an increase in plasma LDL and apo B concentrations. These results point to the need for further investigations on the mechanism by which Se deficiency affects lipoprotein metabolism.

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عنوان ژورنال:
  • The British journal of nutrition

دوره 76 6  شماره 

صفحات  -

تاریخ انتشار 1996